Rangers manager Giovanni Van Bronckhorst got off to a perfect start with a 2-0 win over Sparta Prague, securing their place in the last 32 of the Europa League, while Leicester advanced to the knockout stages with a 3-1 win over Legia Warsaw.
However, Celtic’s chances of progress were dashed by a late Bayer Leverkusen rally from a 2-1 deficit to win 3-2 in Germany.
On Thursday, Real Betis, Lazio, Monaco, Galatasaray, and Olympiakos also qualified for the knockout stages.
Van Bronckhorst sat in the stands as Rangers were defeated 3-1 by Hibernian in the Scottish League Cup semi-final on Sunday.
Alfredo Morelos scored early in both halves to give Rangers the two-goal victory they needed to secure second place in Group A in his first match since officially succeeding Steven Gerrard.
After a first-half blitz of Legia, Leicester will travel to Napoli in two weeks knowing that a point will be enough to advance.
Patson Daka, James Maddison, and Wilfried Ndidi all scored inside 33 minutes against the Polish champions to propel them to the top of the group before kick-off.
All four teams still have a chance to qualify in the group’s final games, with the Foxes leading Napoli and Spartak Moscow by a point and Legia trailing by one.
Celtic have gap to bridge
After losing the lead in Leverkusen, Celtic will have to settle for a place in the Europa Conference League in the new year.
Robert Andrich put the hosts ahead before Josip Juranovic equalized from the spot.
Celtic were on course for their first-ever win in Germany after Jota’s sweet strike 11 minutes into the second half.
But Andrich scored his second goal of the game between Joe Hart’s legs before Moussa Diaby beat him from the edge of the box.
“It was disappointing for the players because they worked so hard, but there’s still a gap between us and them, and that’s what we need to bridge,” Celtic manager Ange Postecoglou said.
With a 2-0 win over Ferencvaros, Betis secured second place in the group behind Leverkusen.
After securing qualification in style, Lazio and Galatasaray will face off in two weeks for the top spot in Group E.
The Italians defeated Lokomotiv Moscow 3-0. According to reports, Lokomotiv Moscow’s head of sports and development Ralf Rangnick is set to join Manchester United.
Ciro Immobile scored two second-half penalties, and Pedro Rodriguez completed the scoring.
Galatasaray now leads the group by three points after eliminating Marseille’s chances of progress in a 4-2 thriller in Istanbul.
West Ham’s impressive return to European football continued with a 2-0 victory over Rapid Vienna, despite David Moyes’ use of a much-changed starting lineup.
For the English, Andriy Yarmolenko and Mark Noble scored.
Real Sociedad must defeat PSV Eindhoven at home in two weeks to advance after losing 2-1 to Monaco.
The French team advanced to the round of 16 after goals from Kevin Volland and Youssouf Fofana helped them win their group.
PSV defeated Sturm Graz 2-0 to move two points ahead of Sociedad in the race for second place.